Welcome on the website of the
Genetics, Epigenetics and Biology of Sarcomas Team
(previously known as the "Biology of Rare Sarcomas Lab" ;-)
With more than 70 histological subtypes and an increasing number (over 150) of described molecular subtypes, sarcomas represent not only a diagnostic challenge for pathologists but also a therapeutic conundrum for oncologists. The discovery of specific genomic alterations, including an abundant number of translocations, greatly improved the diagnosis of sarcomas. Nevertheless, most of these fusion genes remain functionally uncharacterized and the biology of the tumors harboring them still largely unknown, precluding the development of specific therapies. We are therefore interested in i) identifying new sarcoma entities using NGS approaches, ii) investigating their oncogenic determinants and iii) understanding their underlying biology.